As a young adult, Wilma worked with Betty Rubble as a clown at a resort. There, they first met and fell in love with their future husbands, Fred Flintstone and Barney Rubble, who were working there as bellhops.
Wilma and Fred eventually married, and Wilma became a homemaker, keeping house with such prehistoric aids as a baby elephant vacuum cleaner and pelican washing machine. Wilma is a good cook; one of her specialties is "gravelberry pie," the recipe for which she eventually sold to the "Safestone" supermarket chain. Wilma also enjoys volunteering for various charitable and women's organizations in Bedrock, shopping, and occasionally getting to meet the celebrities of their world, including Stony Curtis, Rock Quarry, and Jimmy Darrock.
Wilma later becomes pregnant and gives birth to the couple's only child, Pebbles.
When Pebbles is a teenager, Wilma gains employment as a reporter for one of Bedrock's newspapers, the Daily Granite, under editor Lou Granite. While employed there, Wilma shares various adventures with prehistoric superhero Captain Caveman, who, in a secret identity, also works for the newspaper.
Later still, after Pebbles grows up and leaves home, Wilma starts a successful catering business with her neighbor and friend Betty, before becoming a grandmother to Pebbles' twin children, Chip and Roxy.