Santos was a loyal officer in the Spanish Royal Navy during the Age of Piracy, serving aboard the Silent Mary under the command of Capitán Armando Salazar. He followed his Capitán loyally on hundreds of pirate-hunting expeditions in their quest to eliminate piracy forever across the sea, until eventually they were defeated by a young pirate, crashing into the Devil's Triangle and being transformed into ghosts. Cursed and forced to roam the seas in everlasting torment, he along with his Captain would stop at nothing to take their revenge on the very man who took their lives from them, Captain Jack Sparrow. Several decades later, the Silent Mary was suddenly freed when Jack traded and therefore betrayed his compass causing his worst fear - death - to come true, and the ghost ship immediately set out to avenge their past defeat. They enlisted the help of Sparrow's old enemy, Captain Hector Barbossa, to find the pirate, but soon the latter double-crossed the Spaniards and teamed up with Jack to find the Trident of Poseidon at the Black rock island. The Silent Mary and its crew chased the pirates to the island, where they fought for the Trident at Poseidon's Tomb where the curse ended up being lifted. However, the walls of water surrounding the tomb soon began to close in, and Santos, along with the rest of Salazar's crew, was left behind to drown by his Captain.