An unidentified scientist performs experiments in attempt to increase their intellect. One such animal is an ape he names "Monsieur Mallah" whom is educated for nearly 10 years and becomes his personal assistant. After the scientist is caught in an explosion, Mallah is able to save him and manages to place his disembodied brain in a robotic body. The takes the name "The Brain", with him and Mallah founding the Brotherhood of Evil in attempt to conquer the world.
The Brain, as a brick-build, appears on Mallah's back.